Placental Genome and Maternal-Placental Genetic Interactions: A Genome-Wide and Candidate Gene Association Study of Placental Abruption
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منابع مشابه
Placental Genome and Maternal-Placental Genetic Interactions: A Genome-Wide and Candidate Gene Association Study of Placental Abruption
While available evidence supports the role of genetics in the pathogenesis of placental abruption (PA), PA-related placental genome variations and maternal-placental genetic interactions have not been investigated. Maternal blood and placental samples collected from participants in the Peruvian Abruptio Placentae Epidemiology study were genotyped using Illumina's Cardio-Metabochip platform. We ...
متن کاملGenome-wide and candidate gene association studies of placental abruption.
Placental abruption (PA), a pregnancy-related vascular disorder, is a leading cause of maternal and perinatal morbidity and mortality. The success of identifying genetic susceptibility loci for PA, a multi-factorial heritable disorder, has been limited. We conducted a genome-wide association study (GWAS) and candidate gene association study using 470 PA cases and 473 controls from Lima, Peru. G...
متن کاملAssociation of maternal hypertension with placental abruption.
BACKGROUND Placental abruption is one of the leading causes of maternal mortality and morbidity. Many causes predispose an expecting mother to placental abruption, such as trauma, previous history, smoking, ethnicity and hypertension. The present study concentrated on maternal hypertension as a cause of abruption. METHODS All subjects of this comparative study underwent a complete obstetrical...
متن کاملPlacental abruption.
Placental abruption complicates about 1% of pregnancies and is a leading cause of vaginal bleeding in the latter half of pregnancy. It is also an important cause of perinatal mortality and morbidity. The maternal effect of abruption depends primarily on its severity, whereas its effect on the fetus is determined both by its severity and the gestational age at which it occurs. Risk factors for a...
متن کاملBreastfeeding and placental abruption.
Case report A 32-year-old woman in her ® fth pregnancy presented at 28 weeks’ gestation with a signi® cant, painless, antepartum haemorrhage (APH). She reported intermittent uterine tightenings and backache over the previous week. Routine ultrasound at 20 weeks’ gestation had shown the placenta to be clear of the cervical os and she had no antenatal problems of note. She was a non-smoker and ha...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0116346